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11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2
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DeCS
Descriptor
English
:
11-beta-Hydroxysteroid Dehydrogenase Type 2
Descriptor
Spanish
:
11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 2
Descriptor
Portuguese
:
11-beta-Hidroxiesteróide Desidrogenase Tipo 2
Tree Number:
D08.811.682.047.436.174.600
Definition
English
:
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to
CORTISONE
. It is found predominantly in mineralocorticoid target
tissues
such as the
KIDNEY
;
COLON
;
SWEAT GLANDS
; and the
PLACENTA
. Absence of the enzyme leads to a fatal form of childhood
hypertension
termed, APPARENT MINERALOCORTICOID EXCESS
SYNDROME.
Entry Combination - descr/qualif
English
:
11-beta-Hydroxysteroid Dehydrogenase Type 2
/
deficiency
use
Mineralocorticoid Excess Syndrome, Apparent
History Note
English
:
2004; for 11 BETA-HSD2 use 11 BETA-HYDROXYSTEROID DEHYDROGENASES (NM) 1992-2003
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
38200
Unique Identifier:
D043209
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
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